Yes, it can. Cartographer clusters and connects your people across IDs, browsers, devices, and domains. So a consumer who visits your abc.com site would be connected to all the instances of their identity, including their visit to your def.com site.
Just as publishers can leverage Device Graphs to underpin custom content experiences, advertisers can use the technology to drive custom creative experiences. If users engage with video ads in the desktop environment, for example, then those same users can be targeted with more video enabled ad creatives when they are seen across linked mobile devices.